The RCA and First Reformed Church support different missions and missionaries locally and all around the world. The following missions are supported by First Reformed Church through prayer and offerings.
Partners in Mission (RCA)
| Mr. and Mrs. Roger Scheenstra | Nairobe, Kenya |
Partners in Mission (Other)
| Mr. and Mrs. Victor Atallah | Cyprus (MERF) |
| Mr. and Mrs. Phil Cook | Texas |
| Mr. and Mrs. Dave Eernisse | Wycliffe Bible Translators, Bibleless People Groups, Kenya |
| Mr. and Mrs. Michael Foster | Word of Life, Philippines |
| Mr. and Mrs. Kurt Jackson | Guatemala |
| Mr. and Mrs. Edward Kotynski | Indonesia |
| The Dalachs | Intervarsity, Purdue Calumet |
| Gospel to Asia (Native Missionaries) | |
| Chicagoland Prison Outreach | |
| Erich & Candice Strehl | Paidia, Jerusalem, Israel |
| Welcome Home Orphanage | Mexico |
| David Lantz/ Steve McNary | Church Planters, San Antonio |
| Feed the Children | Reynosa, Mexico |
